It will come as no surprise to anybody who has ever played the game but stepping into the batter's box and making contact with a baseball is hard.
Now imagine hitting the ball out of the yard twice in a single inning.
Sounds impossible, doesn't it?
Well, since June of 1880, the feat has been achieved on 64 occasions, with 61 different big leaguers having slugged soundly twice in a single frame.
From an array of pioneering bats to the trio to have achieved the feat more than once, here is the full list of every Major League Baseballer to have hit two home runs in a single big league inning.
| Player | Team | Opponent | Inning | Date |
| Charley Jones | Boston Red Stockings | Buffalo Bisons | 8th | June 10, 1880 |
| Lou Bierbauer | Brooklyn Ward's Wonders | Buffalo Bisons | 3rd | July 12, 1890 |
| Ed Cartwright | St. Louis Browns | Philadelphia Athletics | 3rd | September 23, 1890 |
| Bobby Lowe | Boston Beaneaters | Cincinnati Reds | 3rd | May 30, 1894 |
| Ken Williams | St. Louis Browns | Washington Senators | 6th | August 7, 1922 |
| Hack Wilson | New York Giants | Philadelphia Phillies | 3rd | July 1, 1925 |
| Bill Regan | Boston Red Sox | Chicago White Sox | 4th | June 16, 1928 |
| Hank Leiber | New York Giants | Chicago Cubs | 2nd | August 24, 1936 |
| Joe DiMaggio | New York Yankees | Chicago White Sox | 5th | June 24, 1936 |
| Andy Seminick | Philadelphia Phillies | Cincinnati Reds | 8th | June 2, 1949 |
| Sid Gordon | New York Giants | Cincinnati Reds | 2nd | July 31, 1949 |
| Al Kaline | Detroit Tigers | Kansas City Athletics | 6th | April 17, 1955 |
| Jim Lemon | Washington Senators | Boston Red Sox | 3rd | September 5, 1959 |
| Joe Pepitone | New York Yankees | Kansas City Athletics | 8th | May 23, 1962 |
| Rick Reichardt | California Angels | Boston Red Sox | 8th | April 30, 1966 |
| Willie McCovey (1) | San Francisco Giants | Houston Astros | 4th | April 12, 1973 |
| John Boccabella | Montreal Expos | Houston Astros | 6th | July 6, 1973 |
| Lee May | Houston Astros | Chicago Cubs | 6th | April 29, 1974 |
| Willie McCovey (2) | San Francisco Giants | Cincinnati Reds | 6th | June 27, 1977 |
| Cliff Johnson | New York Yankees | Toronto Blue Jays | 8th | June 30, 1977 |
| Andre Dawson (1) | Montreal Expos | Atlanta Braves | 3rd | July 30, 1978 |
| Ray Knight | Cincinnati Reds | New York Mets | 5th | May 13, 1980 |
| Von Hayes | Philadelphia Phillies | New York Mets | 1st | June 11, 1985 |
| Andre Dawson (2) | Montreal Expos | Chicago Cubs | 5th | September 24, 1985 |
| Dale Murphy | Atlanta Braves | San Francisco Giants | 6th | July 27, 1989 |
| Ellis Burks | Boston Red Sox | Cleveland Indians | 4th | August 27, 1990 |
| Carlos Baerga | Cleveland Indians | New York Yankees | 7th | April 8, 1993 |
| Joe Carter | Toronto Blue Jays | Baltimore Orioles | 2nd | October 3, 1993 |
| Jeff Bagwell | Houston Astros | Los Angeles Dodgers | 6th | June 24, 1994 |
| Jeff King (1) | Pittsburgh Pirates | San Francisco Giants | 2nd | August 8, 1995 |
| Jeff King (2) | Pittsburgh Pirates | Cincinnati Reds | 4th | April 30, 1996 |
| Sammy Sosa | Chicago Cubs | Houston Astros | 7th | May 16, 1996 |
| Dave Nilsson | Milwaukee Brewers | Minnesota Twins | 6th | May 17, 1996 |
| Mark McGwire | Oakland Athletics | Seattle Mariners | 5th | September 22, 1996 |
| Mike Lansing | Montreal Expos | San Francisco Giants | 6th | May 7, 1997 |
| Gary Sheffield | Florida Marlins | Philadelphia Phillies | 4th | July 13, 1997 |
| Fernando Tatis | St. Louis Cardinals | Los Angeles Dodgers | 3rd | April 23, 1999 |
| Eric Karros | Los Angeles Dodgers | Montreal Expos | 6th | August 22, 2000 |
| Bret Boone | Seattle Mariners | Chicago White Sox | 1st | May 2, 2002 |
| Mike Cameron | Seattle Mariners | Chicago White Sox | 1st | May 2, 2002 |
| Jared Sandberg | Tampa Bay Devil Rays | Los Angeles Dodgers | 5th | June 11, 2002 |
| Nomar Garciaparra | Boston Red Sox | Tampa Bay Devil Rays | 3rd | July 23, 2002 |
| Carl Everett | Texas Rangers | Oakland Athletics | 7th | July 26, 2002 |
| Aaron Boone | Cincinnati Reds | San Diego Padres | 1st | August 9, 2002 |
| Mark Bellhorn | Chicago Cubs | Milwaukee Brewers | 4th | August 29, 2002 |
| Reggie Sanders | Pittsburgh Pirates | St. Louis Cardinals | 5th | August 20, 2003 |
| Juan Rivera | Montreal Expos | Chicago White Sox | 2nd | June 19, 2004 |
| Julio Lugo | Tampa Bay Devil Rays | Baltimore Orioles | 5th | July 22, 2006 |
| Bengie Molina | San Francisco Giants | New York Mets | 5th | May 7, 2007 |
| Magglio Ordonez | Detroit Tigers | Oakland Athletics | 2nd | August 12, 2007 |
| Alex Rodriguez (1) | New York Yankees | Seattle Mariners | 7th | September 5, 2007 |
| Jim Edmonds | Chicago Cubs | Chicago White Sox | 4th | June 21, 2008 |
| David Ortiz | Boston Red Sox | Texas Rangers | 1st | August 12, 2008 |
| Michael Cuddyer | Minnesota Twins | Kansas City Royals | 7th | August 23, 2009 |
| Alex Rodriguez (2) | New York Yankees | Tampa Bay Rays | 6th | October 4, 2009 |
| Juan Uribe | San Francisco Giants | Chicago Cubs | 2nd | September 23, 2010 |
| Pablo Sandoval | San Francisco Giants | Colorado Rockies | 4th | September 18, 2011 |
| Kendrys Morales | Los Angeles | Texas Rangers | 6th | July 30, 2012 |
| Adrian Beltre | Texas Rangers | Baltimore Orioles | 4th | August 22, 2012 |
| Edwin Encarnacion (1) | Toronto Blue Jays | Houston Astros | 7th | July 26, 2013 |
| Mark Trumbo | Baltimore Orioles | Texas Rangers | 7th | April 15, 2016 |
| Edwin Encarnacion (2) | Seattle Mariners | Kansas City Royals | 6th | April 8, 2019 |
| Gleyber Torres | New York Yankees | Pittsburgh Pirates | 8th | September 21, 2022 |
| Mastaka Yoshida | Boston Red Sox | Milwaukee Brewers | 8th | April 23, 2023 |
| Trea Turner | Philadelphia Phillies | Washington Nationals | 8th | August 19, 2023 |